Health and Human Services Public Health Service Food and Drug Administration Center for Drug Evaluation and Research
نویسندگان
چکیده
Modafinil is marketed as Provigil to improve wakefulness in adults with excessive sleepiness associated with narcolepsy, obstructive sleep apnea/hypopnea syndrome, and shift work sleep disorder. The recommended dose in these disorders in adults is 200 mg/day. Its pharmacological mechanism in improving increased wakefulness is not understood. This supplement provides data in support of a claim for the short-term effectiveness of modafinil in ADHD in children and adolescents, at doses of 340 mg/day (in patients < 30 kg) and 425 mg/day (in patients > 30 kg).
منابع مشابه
Memorandum Department Ofhealth and Human Services Public Health Service Food and Drug Administration Center for Drug Evaluation and Research
متن کامل
Memorandum Department of Health and Human Services Date: From: Subject: To: Public Health Service Food and Drug Administration Center for Drug Evaluation and Research
A number of antipsychotic drugs have been available in the US, beginning in the early 1950s with chlorpromazine, and these drugs have proven to be immensely useful in the treatment of various psychotic illnesses, in particular schizophrenia. Several of these drugs are available in parenteral form, e.g., haloperidol and chlorpromazine, for intramuscular (IM) use. Many clinicians have found these...
متن کاملMemorandum Departmkent of Health and Human Services Public Health Service Food and Drug Administration Center for Drug Evaluation and Research
A number of antipsychotic drugs have been available in the US, beginning in the early 1950s with chlorpromazine, and these drugs have proven to be immensely useful in the treatment of various psychotic illnesses, in particular schizophrenia. Several of these drugs are available in parenteral form, e.g., haloperidol and chlorpromazine, for intramuscular (IM) use. Many clinicians have found these...
متن کاملExposure Assessment for Some Pesticides through Rice Consumption in Iran Using a Multiresidue Analysis by GC-MS
In communities which consume rice as main food, importance of risk assessment forcontaminants is always taken into consideration by health authorities. The present study isan attempt for monitoring of 56 pesticides from different chemical groups in rice samplescollected from local markets in Tehran and estimation of daily intake of interested pesticidesthrough this monitoring. A valid method ba...
متن کاملCancer Therapy with Chimeric Antigen Receptors - A Landmark Moment for Cancer Immunotherapy
Submit Manuscript | http://medcraveonline.com Abbreviations: ALL: Acute Lymphoblastic Lymphoma; BLA: Biologics License Application; CAR: Chimeric Antigen Receptor; CD19: Specific Antigen; CBER: Center for Biologics Evaluation and Research; CHOP: Children’s Hospital of Philadelphia; CLL: Chronic Lymphocytic Leukemia; CRS: Cytokine Release Syndrome; CTLA: Cytotoxic T-Lymphocyte Antigen; DNA: Deox...
متن کامل